| Gene Symbol |
TNFRSF4
|
| Gene Synonyms |
ACT35 CD134 IMD16 Ly-70 OX40 Txgp1 TXGP1L |
| Gene Full Name |
TNF receptor superfamily member 4 |
| Gene Summary |
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. Knockout studies in mice suggested that this receptor promotes the expression of apoptosis inhibitors BCL2 and BCL2lL1/BCL2-XL, and thus suppresses apoptosis. The knockout studies also suggested the roles of this receptor in CD4+ T cell response, as well as in T cell-dependent B cell proliferation and differentiation. [provided by RefSeq, Jul 2008] |
| Alternative Names |
ACT35 antigen ATC35 antigen CD134 antigen cell surface antigen lymphoid activation antigene ACT35 MRC OX40 OX40 antigen OX40 cell surface antigen OX40 homologue OX40L receptor TAX transcriptionally-activated glycoprotein 1 receptor Tax-transcriptionally activated glycoprotein 1 tax-transcriptionally activated glycoprotein 1 receptor tumor necrosis factor (ligand) superfamily member 4 tumor necrosis factor receptor superfamily member 4 tumor necrosis factor superfamily member 4 |
| Molecular Weight(MW) |
29kDa(observed:55kDa) |
| Source |
Rabbit |
| Cellular Localization |
Membrane ; Single-pass type I membrane protein |