This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
Alternative Names
aggrecan 1 aggrecan 1 (chondroitin sulfate proteoglycan 1 large aggregating proteoglycan antigen identified by monoclonal antibody A0122) aggrecan epidermal growth factor-like domain-1 aggrecan structural proteoglycan of cartilage cartilage aggregating proteoglycan cartilage-specific proteoglycan core protein chondroitin sulfate proteoglycan 1 chondroitin sulfate proteoglycan core protein 1 CSPCP high density cartilage proteoglycan large aggregating proteoglycan large aggregating proteoglycan antigen proteoglycan proteoglycan core protein