The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and is responsible for ATP-dependent lysis of macrophages through the formation of membrane pores permeable to large molecules. Activation of this nuclear receptor by ATP in the cytoplasm may be a mechanism by which cellular activity can be coupled to changes in gene expression. Multiple alternatively spliced variants have been identified, most of which fit nonsense-mediated decay (NMD) criteria. [provided by RefSeq, Jul 2010]
Alternative Names
ATP agonist non-selective cationic pore-forming protein ATP receptor ATP-gated ion channel splice variant P2X7(k) ligand gated ion channel MGC20089 P2X purinoceptor 7 P2X purinoceptor 7-like p2X receptor 7 P2X7 P2X7 purinoceptor P2X7 receptor P2X7 cervical cancer susceptibility protein P2Z P2Z receptor purinergic receptor P2X ligand gated ion channel 7 purinergic receptor P2X ligand-gated ion channel 7 purinergic receptor P2X7 purnergic receptor P2X 7