Immunofluorescence analysis of C2C12 cells using CELF1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.
Members of the CELF/BRUNOL protein family contain two N-terminal RNA recognition motif (RRM) domains, one C-terminal RRM domain, and a divergent segment of 160-230 aa between the second and third RRM domains. Members of this protein family regulate pre-mRNA alternative splicing and may also be involved in mRNA editing, and translation. This gene may play a role in myotonic dystrophy type 1 (DM1) via interactions with the dystrophia myotonica-protein kinase (DMPK) gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Alternative Names
50 kDa nuclear polyadenylated RNA-binding protein brain protein F41 bruno-like 2 bruno-like protein 2 CELF-1 CUG RNA-binding protein CUG triplet repeat RNA-binding protein 1 CUG-BP- and ETR-3-like factor 1 CUG-BP1 CUGBP Ela deadenylation factor CUG-BP deadenylation factor EDEN-BP EDEN-BP homolog embryo deadenylation element binding protein embryo deadenylation element-binding protein homolog nuclear polyadenylated RNA-binding protein 50-kD RNA-binding protein RNA-binding protein BRUNOL-2 RP23-147D3.7
Immunofluorescence analysis of C2C12 cells using CELF1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.
Additional Information
Form
Liquid
Storage Instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle.
Storage Buffer
Purified antibody in PBS with 0.05% PC300,40% Glycerol.