This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, three catalytically active thioredoxin (TRX) domains, two TRX-like domains and a C-terminal ER-retention sequence. This protein, when bound to cyclophilin B, enhances the rate of immunoglobulin G intermolecular disulfide bonding and antibody assembly. [provided by RefSeq, Dec 2016]
Alternative Names
calcium binding protein intestinal EC 5.3.4.1 endoplasmic reticulum protein 72 endoplasmic reticulum resident protein 70 endoplasmic reticulum resident protein 72 ER protein 70 ER protein 72 protein disu protein disulfide isomerase related protein (calcium-binding protein intestinal-related) protein disulfide isomerase-associated 4 Protein ERp-72 testicular tissue protein Li 137