ICC/IF
Immunofluorescence analysis of C2C12 cells using CHRNA7 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-CHRNA7 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Antigen peptide affinity chromatography |
| Gene Symbol | CHRNA7 |
|---|---|
| Gene Synonyms | a7nAChR Acra7 alpha7 BTX CHRNA7-2 nAchR nAChR7 NACHRA7 NARAD |
| Gene Full Name | cholinergic receptor nicotinic alpha 7 subunit |
| Gene Summary | The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012] |
| Alternative Names | a7 nicotinic acetylcholine receptor acetylcholine receptor acetylcholine receptor alpha 7 neural alpha 7 neuronal nicotinic acetylcholine receptor alpha 7-2 alpha-7 nicotinic cholinergic receptor subunit alpha7 nicotinic receptor alpha7-nAChR bungarotoxin alpha C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha) cholinergic receptor cholinergic receptor nicotinic alpha 7 cholinergic receptor nicotinic alpha 7 (neuronal) cholinergic receptor nicotinic alpha polypeptide 7 CHRFAM7A CHRNA7-DR1 cytotransmitter gated ion channel D-10 nAChR alpha7 neuronal acetylcholine receptor protein alpha-7 chain neuronal nicotinic acetycholine receptor alpha 7 neurotransmitter receptor acra7 nicotinic acetylcholine receptor subunit alpha-7 nicotinic receptor alpha 7 subunit |
| Molecular Weight(MW) | 56kDa |
| Cellular Localization | Cell junction, synapse, postsynaptic cell membrane,Cell membrane |
| SwissProt ID | P36544 |
|---|
ICC/IF
Immunofluorescence analysis of C2C12 cells using CHRNA7 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
