| Product Name | Anti-BCR antibody-RBITC |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | RBITC |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | BCR |
|---|---|
| Gene Synonyms | 5133400C09Rik ALL BCR1 CML D22S11 D22S662 mKIAA3017 PHL |
| Gene Full Name | BCR activator of RhoGEF and GTPase |
| Gene Summary | A reciprocal translocation between chromosomes 22 and 9 produces the Philadelphia chromosome, which is often found in patients with chronic myelogenous leukemia. The chromosome 22 breakpoint for this translocation is located within the BCR gene. The translocation produces a fusion protein which is encoded by sequence from both BCR and ABL, the gene at the chromosome 9 breakpoint. Although the BCR-ABL fusion protein has been extensively studied, the function of the normal BCR gene product is not clear. The unregulated tyrosine kinase activity of BCR-ABL1 contributes to the immortality of leukaemic cells. The BCR protein has serine/threonine kinase activity and is a GTPase-activating protein for p21rac and other kinases. Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2020] |
| Alternative Names | ABL bcr BCR protein BCR RhoGEF and GTPase activating protein bcr/abl bcr/able fusion protein BCR/FGFR1 chimera protein BCR::ABL1 fusion protein breakpoint cluster region breakpoint cluster region homolog c-ABL c-abl oncogene 1 EC 2.7.11.1 FGFR1/BCR chimera protein JTK7 p150 protein kinase renal carcinoma antigen NY-REN-26 RP11-83J21.1 v-abl |
| Molecular Weight(MW) | 143kDa |
| Cellular Localization | Cell junction, synapse, postsynaptic density |
| SwissProt ID | P11274 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
