| Product Name | Anti-UHRF1 antibody-Biotin |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | Biotin |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Antigen peptide affinity chromatography |
| Gene Symbol | UHRF1 |
|---|---|
| Gene Synonyms | Ac2-121 hNP95 hUHRF1 huNp95 ICBP90 Np95 RNF106 TDRD22 |
| Gene Full Name | ubiquitin like with PHD and ring finger domains 1 |
| Gene Summary | This gene encodes a member of a subfamily of RING-finger type E3 ubiquitin ligases. The protein binds to specific DNA sequences, and recruits a histone deacetylase to regulate gene expression. Its expression peaks at late G1 phase and continues during G2 and M phases of the cell cycle. It plays a major role in the G1/S transition by regulating topoisomerase IIalpha and retinoblastoma gene expression, and functions in the p53-dependent DNA damage checkpoint. It is regarded as a hub protein for the integration of epigenetic information. This gene is up-regulated in various cancers, and it is therefore considered to be a therapeutic target. Multiple transcript variants encoding different isoforms have been found for this gene. A related pseudogene exists on chromosome 12. [provided by RefSeq, Feb 2014] |
| Alternative Names | Ac2-121 FLJ21925 Hnp95 Huhrf1 inverted CCAAT box binding protein 90 inverted CCAAT box-binding protein of 90 kDa liver regeneration-related protein LRRG126 MGC138707 mUhrf1 nuclear phosphoprotein 95 nuclear protein 95 nuclear zinc finger protein Np95 RING finger protein 106 RING-type E3 ubiquitin transferase UHRF1 thymus and cell proliferation associated protein transcription factor ICBP90 ub ubiquitin-like PHD and RING finger domain-containing protein 1 ubiquitin-like containing PHD and RING finger domains 1 ubiquitin-like-containing PHD and RING finger domains protein 1 |
| Molecular Weight(MW) | 90kDa |
| Cellular Localization | Nucleus |
| SwissProt ID | Q96T88 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
