This gene is a member of the immunoglobulin superfamily. The encoded poly-Ig receptor binds polymeric immunoglobulin molecules at the basolateral surface of epithelial cells; the complex is then transported across the cell to be secreted at the apical surface. A significant association was found between immunoglobulin A nephropathy and several SNPs in this gene.[provided by RefSeq, Sep 2009]
Alternative Names
hepatocellular carcinoma associated protein TB6 phosphatidylinositol glycan class R Poly Ig receptor poly-Ig receptor polymeric IgA receptor tb6