1190003K14Rik HNA-2 HNA-2a HNA2A NB1 NB1 GP Pdp3 PRV-1 PRV1
Gene Full Name
CD177 molecule
Gene Summary
This gene encodes a glycosyl-phosphatidylinositol (GPI)-linked cell surface glycoprotein that plays a role in neutrophil activation. The protein can bind platelet endothelial cell adhesion molecule-1 and function in neutrophil transmigration. Mutations in this gene are associated with myeloproliferative diseases. Over-expression of this gene has been found in patients with polycythemia rubra vera. Autoantibodies against the protein may result in pulmonary transfusion reactions, and it may be involved in Wegener's granulomatosis. A related pseudogene, which is adjacent to this gene on chromosome 19, has been identified. [provided by RefSeq, Apr 2014]
Alternative Names
cell surface receptor human neutrophil alloantigen 2a human neutrophil antigen 2 NB1 glycoprotein polycythemia rubra vera protein 1