This gene is a member of the myeloid/lymphoid or mixed-lineage leukemia (MLL) family and encodes a nuclear protein with an AT hook DNA-binding domain, a DHHC-type zinc finger, six PHD-type zinc fingers, a SET domain, a post-SET domain and a RING-type zinc finger. This protein is a member of the ASC-2/NCOA6 complex (ASCOM), which possesses histone methylation activity and is involved in transcriptional coactivation. [provided by RefSeq, Jul 2008]
Alternative Names
2.1.1.43 ALR-like protein histone-lysine N-methyltransferase MLL3 histone-lysine N-methyltransferase H3 lysine-4 specific homologous to ALR protein lysine (K)-specific methyltransferase 2C myeloid/lymphoid or mixed-lineage leukemia protein 3