There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]
Alternative Names
mutant serpin family A member 7 RP1-82J11.2 serine (or cysteine) peptidase inhibitor clade A (alpha-1 antipeptidase antitrypsin) member 7 serine (or cysteine) peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7 serine (or cysteine) proteinase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7 serine (or cysteine) proteinase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7 serpin A7 serpin peptidase inhibitor clade A (alpha-1 antiproteinase antitrypsin) member 7 T4-binding globulin TBG Glencoe mutant TBG causing partial TBG deficiency thyroxin-binding globulin thyroxine binding globulin thyroxine-binding globulin precursor