ICC/IF
Immunofluorescence analysis of NIH3T3 cells using CHRNA2 antibody (green). Blue: DAPI fluorescent DNA dye.Cells are fixed in 4% paraformaldehyde at room temperature for 15 minutes.| Product Name | Anti-CHRNA2 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CHRNA2 |
|---|---|
| Gene Synonyms | ACHR Acra-2 Acra2 |
| Gene Full Name | cholinergic receptor nicotinic alpha 2 subunit |
| Gene Summary | Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence. [provided by RefSeq, Nov 2009] |
| Alternative Names | acetylcholine receptor acetylcholine receptor nicotinic alpha 2 (neuronal) cholinergic receptor cholinergic receptor nicotinic alpha 2 cholinergic receptor nicotinic alpha 2 (neuronal) cholinergic receptor nicotinic alpha polypeptide 2 (neuronal) nicotinic acetylcholine receptor nicotinic acetylcholine receptor subunit alpha-2 |
| Molecular Weight(MW) | 60kDa |
| Cellular Localization | Cell junction, Cell membrane |
| SwissProt ID | Q15822 |
|---|
ICC/IF
Immunofluorescence analysis of NIH3T3 cells using CHRNA2 antibody (green). Blue: DAPI fluorescent DNA dye.Cells are fixed in 4% paraformaldehyde at room temperature for 15 minutes.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
