This gene encodes a member of the immunoglobulin receptor superfamily and is one of several Fc receptor-like glycoproteins clustered on the long arm of chromosome 1. The encoded protein contains immunoreceptor-tyrosine activation motifs and immunoreceptor-tyrosine inhibitory motifs in its cytoplasmic domain and may play a role in regulation of the immune system. Mutations in this gene have been associated with rheumatoid arthritis, autoimmune thyroid disease, and systemic lupus erythematosus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Alternative Names
Fc receptor homolog 3 fcR-like protein 3 hIFGP3 IFGP family protein 3 Ig-like superfamily receptor Ig-superfamily protein SPAP2a Ig-superfamily protein SPAP2b Ig-superfamily protein SPAP2c Ig-superfamily protein SPAP2d Ig-superfamily protein SPAP2e immune receptor translocation-associated protein 3 immunoglobulin superfamily receptor translocation associated protein 3 IRTA3 SH2 domain-containing phosphatase anchor protein 2