The protein encoded by this gene is a transcription factor required for the expression of several liver-specific genes. The encoded protein functions as a homodimer and binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Defects in this gene are a cause of maturity onset diabetes of the young type 3 (MODY3) and also can result in the appearance of hepatic adenomas. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Alternative Names
albumin proximal factor hepatic nuclear factor 1 hepatic nuclear factor-1-alpha hnf-1 alpha HNF-1-alpha HNF-1A interferon production regulator factor LF-B1 protein LF-B1 hepatic nuclear factor (HNF1): albumin proximal factor also TCF1 liver-specific transcription factor LF-B1 TCF-1 transcription factor transcription factor 1 Transcription factor 1 hepatic