The protein encoded by this gene is a member of the TNF-receptor superfamily, and contains an intracellular death domain. This receptor can be activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL/APO-2L), and transduces an apoptosis signal. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. Two transcript variants encoding different isoforms and one non-coding transcript have been found for this gene. [provided by RefSeq, Mar 2009]
Alternative Names
apoptosis inducing protein TRICK2A/2B apoptosis inducing receptor TRAIL-R2 cytotoxic TRAIL receptor-2 death domain containing receptor for TRAIL/Apo-2L death receptor 5 dr-5 DR4 homolog Fas-like protein KILLER/DR5 TRAIL death-inducing receptor p53-regulated DNA damage-inducible cell death receptor(killer) sCD262 second apoptosis inducing receptor for TRAIL apoptosis-mediating receptor for TRAIL soluble CD262 TNF-related apoptosis-inducing ligand receptor 2 TNFR family member TNFRSF10B tumor necrosis factor receptor superfamily member 10b tumor necrosis factor receptor-like protein ZTNFR9