| Gene Symbol |
NCOR2
|
| Gene Synonyms |
CTG26 N-CoR N-CoR2 SMAP270 SMRT SMRTE SMRTE-tau TNRC14 TRAC-1 TRAC1 |
| Gene Full Name |
nuclear receptor corepressor 2 |
| Gene Summary |
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.[provided by RefSeq, Apr 2011] |
| Alternative Names |
CTG repeat protein 26 mSMRT beta longer SMRT alpha isoform encoded by GenBank Accession Number AF113001 N-CoR2 nuclear receptor corepressor silencing mediator for retinoid and thyroid hormone receptors silencing mediator of retinoic acid and thyroid hormone receptor silencing mediator of retinoid acid and thyroid hormone receptor silencing mediator of retinoid and thyroid hormone receptors extended isoform splice variant 1 transcriptional corepressor SMRTe T3 receptor-associating factor thyroid- retinoic-acid-receptor-associated corepressor TRAC |
| Molecular Weight(MW) |
273kDa |
| Cellular Localization |
Nucleus |