This gene encodes a member of the netrin family of receptors. This particular protein mediates the repulsive effect of netrin-1 and is a vascular netrin receptor. This encoded protein is also in a group of proteins called dependence receptors (DpRs) which are involved in pro- and anti-apoptotic processes. Many DpRs are involved in embryogenesis and in cancer progression. Two alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Oct 2011]
Alternative Names
C. elegans p53-regulated receptor for death and life protein 1 protein unc-5 homolog 2 protein unc-5 homolog B transmembrane receptor Unc5H2 unc-5 homolog 2 unc-5 homolog B unc5 homolog 2