ICC/IF
Immunofluorescence analysis of NIH3T3 cells using CYP46A1 antibody (green). Blue: DAPI fluorescent DNA dye.Cells are fixed in 4% paraformaldehyde at room temperature for 15 minutes.IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using CYP46A1 antibody with DAB staining.| Product Name | Anti-CYP46A1 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CYP46A1 |
|---|---|
| Gene Synonyms | CH24H CP46 CYP46 |
| Gene Full Name | cytochrome P450 family 46 subfamily A member 1 |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum protein is expressed in the brain, where it converts cholesterol to 24S-hydroxycholesterol. While cholesterol cannot pass the blood-brain barrier, 24S-hydroxycholesterol can be secreted in the brain into the circulation to be returned to the liver for catabolism. [provided by RefSeq, Jul 2008] |
| Alternative Names | CH24H cholesterol 24-monooxygenase cholesterol 24S-hydroxylase cholestrol 24-hydroxylase cytochrome P450 46A1 cytochrome P450 46a1 (cholesterol 24-hydroxylase) cytochrome P450 family 46 subfamily A polypeptide 1 cytochrome P450 subfamily 46 (cholesterol 24-hydroxylase) |
| Molecular Weight(MW) | 56kDa |
| Cellular Localization | Endoplasmic reticulum membrane;Microsome membrane;Postsynapse;Presynapse;Cell projection, dendrite |
| SwissProt ID | Q9Y6A2 |
|---|
ICC/IF
Immunofluorescence analysis of NIH3T3 cells using CYP46A1 antibody (green). Blue: DAPI fluorescent DNA dye.Cells are fixed in 4% paraformaldehyde at room temperature for 15 minutes.
IF-P
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using CYP46A1 antibody with DAB staining.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
