| Gene Symbol |
ORAI1
|
| Gene Synonyms |
CRACM1 D730049H07Rik IMD9 orai-1 ORAT1 RGD1311873 TAM2 TMEM142A |
| Gene Full Name |
ORAI calcium release-activated calcium modulator 1 |
| Gene Summary |
The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011] |
| Alternative Names |
calcium release-activated calcium channel 1 calcium release-activated calcium modulator 1 FLJ14466 Orai1 protein orai-1 transmembrane protein 142A |
| Molecular Weight(MW) |
32kDa(observed:37kDa) |
| Cellular Localization |
Cell membrane;Basolateral cell membrane |