| Gene Symbol |
ROR1
|
| Gene Synonyms |
2810404D04Rik dJ537F10.1 NTRKR1 |
| Gene Full Name |
receptor tyrosine kinase like orphan receptor 1 |
| Gene Summary |
This gene encodes a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system. The encoded protein is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2012] |
| Alternative Names |
MGC99659 neurotrophic tyrosine kinase receptor-related 1 receptor tyrosine kinase like orphan receptor 1 T-ROR1 tyrosine-protein kinase transmembrane receptor ROR1 |
| Molecular Weight(MW) |
104kDa(observed:95kDa) |
| Cellular Localization |
Membrane;Cell projection, axon |