| Product Name | Anti-CYP7A1 antibody-DBCO |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | DBCO |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CYP7A1 |
|---|---|
| Gene Synonyms | CHAP CP7A CYP7 CYP7S1 CYPVII CYPVIIc |
| Gene Full Name | cytochrome P450 family 7 subfamily A member 1 |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This endoplasmic reticulum membrane protein catalyzes the first reaction in the cholesterol catabolic pathway in the liver, which converts cholesterol to bile acids. This reaction is the rate limiting step and the major site of regulation of bile acid synthesis, which is the primary mechanism for the removal of cholesterol from the body. Polymorphisms in the promoter of this gene are associated with defects in bile acid synthesis. [provided by RefSeq, Feb 2010] |
| Alternative Names | 24-hydroxycholesterol 7-alpha-hydroxylase cholesterol 7-alpha hydroxylase (CYP7) (EC 1.14.13.17) cholesterol 7-alpha-hydroxylase cholesterol 7-alpha-hydroxylase (EC 1.14.13.17) cholesterol 7-alpha-monooxygenase cholesterol 7alpha-hydroxylase CYPVII cytochrome P450 (cholesterol hydroxylase 7 alpha) cytochrome P450 7a1 cytochrome P450 family 7 subfamily A polypeptide 1 cytochrome P450 subfamily VIIA polypeptide 1 |
| Molecular Weight(MW) | 57kDa(observed：50kDa) |
| Cellular Localization | Endoplasmic reticulum membrane;Microsome membrane |
| SwissProt ID | P22680 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
