ICC/IF
Immunofluorescence analysis of NIH3T3 cells using GHR antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-GHR antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | GHR |
|---|---|
| Gene Synonyms | GHBP GHIP GHR/BP |
| Gene Full Name | growth hormone receptor |
| Gene Summary | This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jun 2011] |
| Alternative Names | GH receptor GHRD56 missing exon5 and 6 growth hormone binding protein growth hormone receptor growth hormone receptor precursor Growth hormone receptor precursor (GH receptor) (GH binding protein) (GHBP) (Serum binding protein) growth hormone receptor variant d5-6 growth hormone receptor/binding protein growth hormone receptor/binding protein precursor growth hormone receptor/binding protein high molecular weight growth hormone receptor/binding protein low molecular weight MGC124963 MGC156665 mutant growth hormone receptor serum binding protein somatotropin receptor |
| Molecular Weight(MW) | 71kDa |
| Cellular Localization | Cell membrane;Secreted |
| SwissProt ID | P10912 |
|---|
ICC/IF
Immunofluorescence analysis of NIH3T3 cells using GHR antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
