IHC
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissues using SREBF1 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human liver tissues using SREBF1 antibody with DAB staining.IHC
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using SREBF1 antibody with DAB staining.| Product Name | Anti-SREBF1 antibody-poly-HRP |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | poly-HRP |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | SREBF1 |
|---|---|
| Gene Synonyms | ADD-1 ADD1 bHLHd1 HMD I79_010155 IFAP2 SREBP-1 SREBP-1c SREBP1 |
| Gene Full Name | sterol regulatory element binding transcription factor 1 |
| Gene Summary | This gene encodes a basic helix-loop-helix-leucine zipper (bHLH-Zip) transcription factor that binds to the sterol regulatory element-1 (SRE1), which is a motif that is found in the promoter of the low density lipoprotein receptor gene and other genes involved in sterol biosynthesis. The encoded protein is synthesized as a precursor that is initially attached to the nuclear membrane and endoplasmic reticulum. Following cleavage, the mature protein translocates to the nucleus and activates transcription. This cleaveage is inhibited by sterols. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Alternative promoter usage and splicing result in multiple transcript variants, including SREBP-1a and SREBP-1c, which correspond to RefSeq transcript variants 2 and 3, respectively. [provided by RefSeq, Nov 2017] |
| Alternative Names | adipocyte determination- and differentiation-dependent factor 1 class D basic helix-loop-helix protein 1 nt-SREBP1 SREBP-1 SREBP1 sterol regulatory element binding protein 1 sterol regulatory element binding protein-1 sterol regulatory element binding-protein 1 Sterol regulatory element-binding transcription factor 1 |
| Molecular Weight(MW) | 121kDa |
| Cellular Localization | Endoplasmic reticulum membrane;Golgi apparatus membrane;Cytoplasmic vesicle, COPII-coated vesicle membrane;Nucleus |
| SwissProt ID | P36956 |
|---|
IHC
Immunohistochemical analysis of paraffin-embedded Human liver cancer tissues using SREBF1 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human liver tissues using SREBF1 antibody with DAB staining.
IHC
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissues using SREBF1 antibody with DAB staining.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
