Tumor necrosis factor (TNF; see MIM 191160) receptor-associated factors, such as TRAF7, are signal transducers for members of the TNF receptor superfamily (see MIM 191190). TRAFs are composed of an N-terminal cysteine/histidine-rich region containing zinc RING and/or zinc finger motifs; a coiled-coil (leucine zipper) motif; and a homologous region that defines the TRAF family, the TRAF domain, which is involved in self-association and receptor binding.[supplied by OMIM, Apr 2004]
Alternative Names
DKFZp586I021 MGC7807 ring finger and WD repeat domain 1 RING finger and WD repeat-containing protein 1 RING finger protein 119 RING zinc finger and WD40 repeats containing protein RING-type E3 ubiquitin transferase TRAF7 TNF receptor-associated factor 7 E3 ubiquitin protein ligase