The protein encoded by this gene is a member of the 7 transmembrane-spanning G protein-coupled receptor family, and functions as a receptor for the endogenous, opioid-related neuropeptide, nociceptin/orphanin FQ. This receptor-ligand system modulates a variety of biological functions and neurobehavior, including stress responses and anxiety behavior, learning and memory, locomotor activity, and inflammatory and immune responses. A promoter region between this gene and the 5'-adjacent RGS19 (regulator of G-protein signaling 19) gene on the opposite strand functions bi-directionally as a core-promoter for both genes, suggesting co-operative transcriptional regulation of these two functionally related genes. Alternatively spliced transcript variants have been described for this gene. A recent study provided evidence for translational readthrough in this gene, and expression of an additional C-terminally extended isoform via the use of an alternative in-frame translation termination codon. [provided by RefSeq, Dec 2017]
Alternative Names
a novel member of the opiod receptor family alternatively spliced variant e of KOR3 G protein-coupled receptor G-protein coupled receptor G-protein-coupled receptor K3 opiate receptor kappa-type 3 opioid receptor kappa3-related opioid receptor KOR-3E KOR3A KOR3B KOR3C LC132 Receptor-Like N/OFQ receptor nociceptin receptor ORL1 nociceptin/ orphaninFQ receptor nociceptin/orphanin FQ receptor opiate receptor-like 1 opioid receptor opioid receptor-like 1 OPPRL1 OPRL1 ORL1 orphanin FQ receptor orphanin FQ receptor-a orphanin FQ receptor-b orphanin FQ receptor-e peptide receptor ROR-C seven transmembrane G protein-coupled receptor splice variant of KOR-3 gene