The protein encoded by this gene is a membrane calcium channel subunit that is activated by the calcium sensor STIM1 when calcium stores are depleted. This type of channel is the primary way for calcium influx into T-cells. Defects in this gene are a cause of immune dysfunction with T-cell inactivation due to calcium entry defect type 1 (IDTICED1). [provided by RefSeq, Sep 2011]
Alternative Names
calcium release-activated calcium channel 1 calcium release-activated calcium modulator 1 FLJ14466 Orai1 protein orai-1 transmembrane protein 142A