| Gene Symbol |
GABRA1
|
| Gene Synonyms |
DEE19 ECA4 EIEE19 EJM EJM5 GABAA-alpha1 GABAAR-alpha1 Gabra-1 |
| Gene Full Name |
gamma-aminobutyric acid type A receptor subunit alpha1 |
| Gene Summary |
This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
| Alternative Names |
GABA(A) receptor subunit alpha-1 GABA(A) receptor alpha 1 GABAA alpha 1 GABAAR alpha1 GABAAR subunit alpha-1 GABRA 1 gamma-aminobutyric acid gamma-aminobutyric acid (GABA) A receptor alpha 1 gamma-aminobutyric acid (GABA) A receptor subunit alpha 1 gamma-aminobutyric acid (GABA-A) receptor subunit alpha 1 gamma-aminobutyric acid A receptor alpha 1 gamma-aminobutyric acid type A receptor alpha1 subunit |
| Molecular Weight(MW) |
51kDa(observed:55kDa) |
| Source |
Rabbit |
| Cellular Localization |
Postsynaptic cell membrane;Cell membrane;Cytoplasmic vesicle membrane |