| Gene Symbol |
MMP9
|
| Gene Synonyms |
B/MMP9 CLG4B Gel B GELB MANDP2 MMP-9 pro-MMP-9 |
| Gene Full Name |
matrix metallopeptidase 9 |
| Gene Summary |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008] |
| Alternative Names |
92 kDa gelatinase 92 kDa type IV collagenase 92kD gelatinase 92kD type IV collagenase CLG4B collagenase type IVB gelatinase B Gelatinase-B GELB macrophage gelatinase matrix metallo protease matrix metallopeptidase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase) matrix metalloproteinase matrix metalloproteinase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase) matrix metalloproteinase 9 (gelatinase B 92kDa matrix metalloproteinase 9 (gelatinase B 92kDa gelatinase 92kDa type IV collagenase) Matrix metalloproteinase9 MMP MMP-9 MMP9 MMPs type V collagenase |
| Molecular Weight(MW) |
78kDa |
| Source |
Rabbit |
| Cellular Localization |
Secreted, extracellular space, extracellular matrix |