This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008]
Alternative Names
17-beta-HSD 5 17HSD type 5 20 alpha-hydroxysteroid dehydrogenase 20alpha-hydroxysteroid dehydrogenase 3beta-hydroxysteroid 3-dehydrogenase aldo-keto reductase C aldo-keto reductase family 1 member C1 (aldehyde reductase) chlordecone reductase homolog chlordecone reductase homolog HAKRC dihydrodiol dehydrogenase 1 dihydrodiol dehydrogenase 1/2 dihydrodiol dehydrogenase 1 20-alpha (3-alpha)-hydroxysteroid dehydrogenase estradiol 17-beta-dehydrogenase (A-specific) hepatic dihydrodiol dehydrogenase high-affinity hepatic bile acid-binding protein hydroxysteroid 17-beta dehydrogenase 5 indanol dehydrogenase oxidoreductase RP11-69D4.1 trans-1 2-dihydrobenzene-1 2-diol dehydrogenase type II 3-alpha-hydroxysteroid dehydrogenase