| Gene Symbol |
GZMH
|
| Gene Synonyms |
C11 CCP-1/C11 CCP-X CCP1 CCPI CGL-1 CGL-2 CGL1 CSP-B CSP-C CSPB Ctla-1 CTLA1 CTSGL1 CTSGL2 GZB HLP RNKP-1 SECT |
| Gene Full Name |
granzyme H |
| Gene Summary |
This gene encodes a member of the peptidase S1 family of serine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate a chymotrypsin-like protease. This protein is reported to be constitutively expressed in the NK (natural killer) cells of the immune system and may play a role in the cytotoxic arm of the innate immune response by inducing target cell death and by directly cleaving substrates in pathogen-infected cells. This gene is present in a gene cluster with another member of the granzyme subfamily on chromosome 14. [provided by RefSeq, Nov 2015] |
| Alternative Names |
alternatively spliced cathepsin G-like 1 cathepsin G-like 2 protein h-CCPX CGL-2 CGL2 CTLA1 cytotoxic cell protease 1 cytotoxic serine protease B cytotoxic T-lymphocyte proteinase cytotoxic T-lymphocyte proteinase 2 cytotoxic T-lymphocyte-associated serine esterase 1 cytotoxin serine protease-C cytotoxin serine protease-C precursor fragmentin fragmentin 2 fragmentin-2 GLP I GLP III GLP-1 granzyme B (granzyme 2 cytotoxic T-lymphocyte-associated serine esterase 1) granzyme-like protein 1 granzyme-like protein I Gzmb GZMH GZMH/GZMB human lymphocyte protein natural killer cell protease 1 proteolytic serine esterase serine protease serine protease-like protein precursor T-cell serine protease 1-3E T-cell specific protein CCPI precursor |
| Molecular Weight(MW) |
27kDa |
| Source |
Rabbit |
| Cellular Localization |
Cytolytic granule |