ICC/IF
Immunofluorescence analysis of SK-N-SH cells using PTGIS antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-PTGIS antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Antigen peptide affinity chromatography |
| Gene Symbol | PTGIS |
|---|---|
| Gene Synonyms | CYP8 CYP8A1 PGIS PTGI |
| Gene Full Name | prostaglandin I2 synthase |
| Gene Summary | This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. However, this protein is considered a member of the cytochrome P450 superfamily on the basis of sequence similarity rather than functional similarity. This endoplasmic reticulum membrane protein catalyzes the conversion of prostglandin H2 to prostacyclin (prostaglandin I2), a potent vasodilator and inhibitor of platelet aggregation. An imbalance of prostacyclin and its physiological antagonist thromboxane A2 contribute to the development of myocardial infarction, stroke, and atherosclerosis. [provided by RefSeq, Jul 2008] |
| Alternative Names | cytochrome P450 family 8 subfamily A polypeptide 1 hydroperoxy icosatetraenoate dehydratase MGC126858 MGC126860 prostaglandin I2 (prostacyclin) synthase prostaglandin I2 synthase |
| Molecular Weight(MW) | 57kDa |
| Source | Rabbit |
| Cellular Localization | Endoplasmic reticulum membrane |
| SwissProt ID | Q16647 |
|---|
ICC/IF
Immunofluorescence analysis of SK-N-SH cells using PTGIS antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
