| Product Name | Anti-SPAG1 antibody-PE-Cy7 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | PE-Cy7 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | SPAG1 |
|---|---|
| Gene Synonyms | CILD28 CT140 DNAAF13 HEL-S-268 HSD-3.8 SP75 TPIS |
| Gene Full Name | sperm associated antigen 1 |
| Gene Summary | The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein. [provided by RefSeq, Jul 2008] |
| Alternative Names | dynein axonemal assembly factor 13 epididymis secretory protein Li 268 infertility-related sperm protein Spag-1 tetratricopeptide repeat-containing protein TPR-containing protein involved in spermatogenesis |
| Molecular Weight(MW) | 103kDa（observed：125kDa) |
| Source | Rabbit |
| Cellular Localization | Cytoplasm ;Dynein axonemal particle |
| SwissProt ID | Q07617 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
