| Product Name | Anti-ERBB2 antibody-RBITC |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description |
|
| Immunogen | Polypeptide |
| Conjugation | RBITC |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | ERBB2 |
|---|---|
| Gene Synonyms | c-ERB-2 c-ERB2 c-erbB2 c-neu CD340 Erbb-2 HER-2 HER-2/neu HER2 l11Jus8 mKIAA3023 MLN 19 MLN-19 NEU NGL p185(erbB2) TKR1 VSCN2 |
| Gene Full Name | erb-b2 receptor tyrosine kinase 2 |
| Gene Summary | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] |
| Alternative Names | approximately 68 kDa secreted autoinhibitor glycoprotein avian erythroblastosis oncogene B 2 c-erb B2/neu protein c-erbB-2 CD antigen CD340 erb-b2 erbb 2 erbB2 ErbB2 (pTyr1139) ErbB2 (pY1139) ErbB2 phospho Y1139 her 2 HER2 receptor HER2/neu receptor herstatin human epidermal growth factor receptor 2 metas metastatic lymph node gene 19 protein Neu oncogene neuro/glioblastoma derived oncogene homolog neuroblastoma/glioblastoma derived oncogene homolog p185erbB2 phospho ErbB2 proto-oncogene c-ErbB-2 proto-oncogene NEU tyrosine kinase-type cell surface receptor HER2 v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2 v-erb-b2 erythroblastic leukemia viral oncogene homolog 2 neuro/glioblastoma derived oncogene homolog |
| Molecular Weight(MW) | 137kDa（observed：180kDa) |
| Source | Rabbit |
| Cellular Localization | Cell membrane;Cell projection, ruffle membrane;Early endosome;Cytoplasm, perinuclear region;Nucleus;Cytoplasm Nucleus |
| SwissProt ID | P04626 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
