This gene encodes the alpha subunit of a transmembrane receptor for collagens and related proteins. The encoded protein forms a heterodimer with a beta subunit and mediates the adhesion of platelets and other cell types to the extracellular matrix. Loss of the encoded protein is associated with bleeding disorder platelet-type 9. Antibodies against this protein are found in several immune disorders, including neonatal alloimmune thrombocytopenia. This gene is located adjacent to a related alpha subunit gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Alternative Names
alpha 2 integrin alpha 2 subunit of VLA-2 receptor BDPLT9 CD49 antigen-like family member B collagen receptor glycoprotein Ia human platelet alloantigen 5 human platelet alloantigen system 5 integrin alpha 2 integrin alpha 2 (CD49B alpha 2 subunit of VLA-2 receptor) platelet antigen Br platelet glycoprotein GPIa platelet glycoprotein Ia platelet membrane glycoprotein Ia very late activation protein 2 receptor alpha-2 subunit very late activation receptor alpha-2 subunit very late activation receptor subunit alpha-2 VLA-2 receptor alpha 2 subunit VLA2 receptor