The protein encoded by this gene is highly similar to Cdc 37, a cell division cycle control protein of Sacchromyces cerevisiae. This protein is a molecular chaperone with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. [provided by RefSeq, Jul 2008]
Alternative Names
CDC 37 CDC37 CDC37 (cell division cycle 37 S. cerevisiae homolog) CDC37 (cell division cycle 37 S. cerevisiae homolog) CDC37 cell division cycle 37 homolog Cdc37 homolog CDC37 protein cell division cycle 37 homolog hsp90 chaperone protein kinase-targeting subunit p50Cdc37