ICC/IF
Immunofluorescence analysis of Hela cells using BCAR1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Product Name | Anti-BCAR1 antibody-AF488 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Polypeptide |
| Conjugation | AF488 |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Antigen peptide affinity chromatography |
| Gene Symbol | BCAR1 |
|---|---|
| Gene Synonyms | CAS CAS1 CASS1 CRKAS P130CAS |
| Gene Full Name | BCAR1 scaffold protein, Cas family member |
| Gene Summary | The protein encoded by this gene is a member of the Crk-associated substrate (CAS) family of scaffold proteins, characterized by the presence of multiple protein-protein interaction domains and many serine and tyrosine phosphorylation sites. The encoded protein contains a Src-homology 3 (SH3) domain, a proline-rich domain, a substrate domain which contains 15 repeat of the YxxP consensus phosphorylation motif for Src family kinases, a serine-rich domain, and a bipartite Src-binding domain, which can bind both SH2 and SH3 domains. This adaptor protein functions in multiple cellular pathways, including in cell motility, apoptosis and cell cycle control. Dysregulation of this gene can have a wide range of effects, affecting different pathways, including cardiac development, vascular smooth muscle cells, liver and kidney function, endothelial migration, and cancer. [provided by RefSeq, Sep 2017] |
| Alternative Names | BCA1 BCAR1 Cas family scaffold protein BCAR1 Cas family scaffolding protein breast cancer anti-estrogen resistance 1 Cas scaffolding protein family member 1 CRK-associated substrate Crk-associated substrate p130Cas OTTHUMP00000174941 p130 Cas p130cas p130Cas (pTyr410) p130Cas (pY410) p130Cas phospho phospho p130Cas v-crk-associated tyrosine kinase substrate |
| Molecular Weight(MW) | 93kDa（observed：130kDa) |
| Source | Rabbit |
| Cellular Localization | Cell junction, focal adhesion;Cytoplasm;Cell projection, axon |
| SwissProt ID | P56945 |
|---|
ICC/IF
Immunofluorescence analysis of Hela cells using BCAR1 antibody (green). Blue: DAPI fluorescent DNA dye. Red: Actin filaments have been labeled with Omnimabs® 594-Phalloidin.| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
