| Gene Symbol |
WDR11
|
| Gene Synonyms |
BRWD2 DR11 HH14 SRI1 WDR15 |
| Gene Full Name |
WD repeat domain 11 |
| Gene Summary |
This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This gene is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus. [provided by RefSeq, Jul 2008] |
| Alternative Names |
bromodomain and WD repeat-containing protein 2 sensitization to ricin complex subunit 1 WD repeat domain 15 WD repeat-containing protein 15 |
| Molecular Weight(MW) |
136kDa |
| Source |
Rabbit |
| Cellular Localization |
Cytoplasm, cytoskeleton, cilium basal body;Cytoplasm;Nucleus;Cytoplasm, cytoskeleton, cilium axoneme;Cytoplasmic vesicle;Golgi apparatus, trans-Golgi network |