| Product Name | Anti-STAT3 antibody-AF700 |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant protein |
| Conjugation | AF700 |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Species Reactivity | HumanMouseRat |
| Purification | Affinity purified |
| Gene Symbol | STAT3 |
|---|---|
| Gene Synonyms | APRF HIES ADMIO ADMIO1 1110034C02Rik |
| Gene Full Name | signal transducer and activator of transcription 3 |
| Gene Summary | The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. [provided by RefSeq, Aug 2020] |
| Alternative Names | acute phase response factor acute-phase response factor DNA-binding protein APRF FLJ20882 MGC16063 signal transducer and activator of transcription 3 (acute-phase response factor) STAT Stat3 transcription factor |
| Molecular Weight(MW) | 88kDa（observed：100kDa) |
| Cellular Localization | Cytoplasm，Nucleus. |
| SwissProt ID | P40763 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
