| Product Name | Anti-NF-kB P105/P50 antibody-Biotin |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | Recombinant protein |
| Conjugation | Biotin |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG |
| Host Species | Mouse |
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Affinity purified |
| Gene Symbol | NFKB1 |
|---|---|
| Gene Synonyms | CVID12 EBP-1 KBF1 NF-kappa-B1 NF-kappaB NF-kappaB1 NF-kappabeta NF-kB NF-KB1 NFkappaB NFKB-p105 NFKB-p50 p105 p50 p50/p105 |
| Gene Full Name | nuclear factor kappa B subunit 1 |
| Gene Summary | This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. NFKB is a critical regulator of the immediate-early response to viral infection. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed. [provided by RefSeq, Aug 2020] |
| Alternative Names | DKFZp686C01211 DNA-binding factor KBF1 EBP-1 MGC54151 NF kappaB1 NF KB NF-kappa-B1 p84/NF-kappa-B1 p98 NF-kappaB p50 NF-kB p50/p105 nuclear factor nuclear factor kappa b nuclear factor kappa-B DNA binding subunit nuclear factor kappaB p50 nuclear factor NF-kappa-B p50 nuclear factor NF-kappa-B p50 subunit nuclear factor of kappa light chain gene enhancer in B-cells 1 p105 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 p105 p105 p50 subunit of NF kappaB p50/p105 transcription factor p105 NF-kappa B precursor |
| Molecular Weight(MW) | 105kDa（observed：100kDa) |
| Cellular Localization | Cytoplasm, Nucleus. |
| SwissProt ID | P19838 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% sodium azide,40% Glycerol. |
