ELISA
Coat the plate with immunizing antigen.Blue line： Immune serum; Orange line: Pre-immune serum.| Product Name | Anti-Caspase-8 antibody |
|---|---|
| Antibody Type | Primary Antibodies |
| Product description |
|
| Immunogen | Polypeptide |
| Clonality | Polyclonal |
|---|---|
| Isotype | IgG |
| Host Species | Rabbit |
| Tested Applications | ELISA |
| ELISA:1:1000-1:10000 |
|
| Species Reactivity | HumanMouseRat |
| Concentration | 1mg/ml |
| Purification | Protein A |
| Gene Symbol | CASP8 |
|---|---|
| Gene Synonyms | ALPS2B CAP4 CASP-8 FLICE MACH MCH5 |
| Gene Full Name | caspase 8 |
| Gene Summary | This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008] |
| Alternative Names | apoptotic cysteine protease apoptotic protease Mch-5 Casp8 caspase 8 apoptosis-related cysteine peptidase caspase 8 apoptosis-related cysteine protease caspase precursor Caspase-8 precursor caspase-8s Caspase8 EC 3.4.22.61 FADD-homologous ICE/CED-3-like protease FADD-like ICE Fas-linked ICE-like protease flice FLJ17672 ICE-like apoptotic protease 5 ICE8 MACH-alpha-1/2/3 protein MACH-beta-1/2/3/4 protein MGC78473 MORT1-associated ced-3 homolog OTTHUMP00000163720 OTTHUMP00000165063 OTTHUMP00000206557 OTTHUMP00000206581 |
| Molecular Weight(MW) | 55kDa |
| Source | Rabbit |
| Cellular Localization | Cytoplasm;Nucleus;Cell projection, lamellipodium |
| SwissProt ID | Q14790 |
|---|
ELISA
Coat the plate with immunizing antigen.Blue line： Immune serum; Orange line: Pre-immune serum.| Application Notes | ELISA:1:1000-1:10000 |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Shipped at 4°C. Store at +4°C short term (1-2 weeks). Store at -20°C long term. Avoid freeze / thaw cycle. |
| Storage Buffer | Purified antibody in PBS with 0.05% PC300,40% Glycerol. |
