This gene is a member of the Src family of protein tyrosine kinases (PTKs). The encoded protein is a key signaling molecule in the selection and maturation of developing T-cells. It contains N-terminal sites for myristylation and palmitylation, a PTK domain, and SH2 and SH3 domains which are involved in mediating protein-protein interactions with phosphotyrosine-containing and proline-rich motifs, respectively. The protein localizes to the plasma membrane and pericentrosomal vesicles, and binds to cell surface receptors, including CD4 and CD8, and other signaling molecules. Multiple alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Aug 2016]
Alternative Names
EC 2.7.10.2 kinase Lck leukocyte C-terminal Src kinase lymphocyte cell-specific protein-tyrosine kinase lymphocyte protein tyrosine kinase lymphocyte-specific protein tyrosine kinase OTTHUMP00000008640 OTTHUMP00000008740 OTTHUMP00000008741 p56(LSTRA) protein-tyrosine kinase proto-oncogene tyrosine-protein kinase LCK RP4-675E8.4 t cell-specific protein-tyrosine kinase T-lymphocyte specific protein tyrosine kinase p56lck tyr