The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine is a pleiotropic cytokine involved in various immune responses, inflammatory processes, and hematopoiesis. This cytokine is produced by monocytes and macrophages as a proprotein, which is proteolytically processed and released in response to cell injury, and thus induces apoptosis. This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. It has been suggested that the polymorphism of these genes is associated with rheumatoid arthritis and Alzheimer's disease. [provided by RefSeq, Jul 2008]
Alternative Names
CTLA8 hematopoietin-1 IL 1 a IL 1伪 IL17 IL1A IL1伪 ILN Interleukin interleukin 17 Interleukin-17A Interleukin1 alpha preinterleukin 1 alpha pro-interleukin-1-alpha RP23-160G19.8