This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c'', and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is known as the D subunit and is found ubiquitously. [provided by RefSeq, Jul 2008]
Alternative Names
32 kDa accessory protein ATPase H+ transporting lysosomal (vacuolar proton pump) 42 kDa ATPase H+ transporting lysosomal (vacuolar proton pump) member D ATPase H+ transporting lysosomal 38kDa V0 subunit D ATPase H+ transporting lysosomal 38kDa V0 subunit d1 ATPase H+ transporting lysosomal V0 subunit D1 ATPase H+ transporting V0 subunit D FLJ43534 H(+)-transporting two-sector ATPase subunit D lysosomal 38kDa physophilin V-ATPase 40 KDa accessory protein V-ATPase AC39 subunit V-ATPase subunit d 1 V-ATPase subunit D V-type proton ATPa vacuolar proton pump subunit d 1