A930022O17Rik CGI-PDE CGI-PDE A CGI-PDE-A HTNB RNPDE3A
Gene Full Name
phosphodiesterase 3A
Gene Summary
This gene encodes a member of the cGMP-inhibited cyclic nucleotide phosphodiesterase (cGI-PDE) family. cGI-PDE enzymes hydrolyze both cAMP and cGMP, and play critical roles in many cellular processes by regulating the amplitude and duration of intracellular cyclic nucleotide signals. The encoded protein mediates platelet aggregation and also plays important roles in cardiovascular function by regulating vascular smooth muscle contraction and relaxation. Inhibitors of the encoded protein may be effective in treating congestive heart failure. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011]
Alternative Names
cAMP phosphodiesterase myocardial cGMP-inhibited cGI-PDE CGI-PDE A cGMP-inhibited 3' 5'-cyclic phosphodiesterase A cGMP-inhibited 3' 5'-cyclic phosphodiesterase A PDE3A cGMP-inhibited cAMP phosphodiesterase cGMP-inhibited phosphodiesterase cyclic GMP-inhibited phosphodiesterase A cyclic nucleotide phosphodiesterase phosphodiesterase 3A cGMP inhibited phosphodiesterase 3A cGMP-inhibited