This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development. Mutations in this gene cause Alexander disease, a rare disorder of astrocytes in the central nervous system. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Molecular Weight(MW)
50kd
Cellular Localization
Cytoplasm,
Intermediate filament
Application
IHC
Formalin-fixed, paraffin-embedded heat retrieval tissue section of rat brain stained with 1:400 Monoclonal Anti-Glial Fibrillary Acidic Protein (GFAP)-Cy3™ antibody (Original magnification: 100X).
Application Notes
IHC:1:100-1000
Additional Information
Storage Instructions
2-8°C
Storage Buffer
PBS with 0.1% sodium azide and 50% glycerol, pH 7.2