This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]
Molecular Weight(MW)
35 kDa(Observed band size: 38 kDa)
Function
SYP Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity. Belongs to the synaptophysin/synaptobrevin family. Homohexamer or homotetramer. Note: This description may include information from UniProtKB.
Cellular Localization
Cytoplasmic vesicle,Membrane,Synapse,Synaptosome
Application
WB
Western blot analysis of Synaptophysin in mouse brain , rat brain lysates and using Synaptophysin Goat pAb.
IF
Immunofluorescence analysis of Synaptophysin (Green) in mouse brain tissue using Synaptophysin Goat pAb, and DAPI(Blue)