4720,4733,CG8651,Dmel\CG8651,DMTRXIII,l(3)bx[v],l(3)j14A6,l(3)j3A2,l(3)s5452,NR0A5,R-bx,Rg-bx,tqrx,Trx,TrX,TRX,Trx-C,trx-g,Trx-G,Trx/MLL,trxG,TrxG,trxI and trxII
Gene Full Name
trithorax
Gene Summary
Enables several functions, including protein homodimerization activity,protein methyltransferase activity,and protein phosphatase 1 binding activity. Involved in several processes, including germ cell migration,haltere development,and positive regulation of transcription elongation by RNA polymerase II. Located in nucleus and polytene chromosome band. Part of MLL1/2 complex,histone acetyltransferase complex,and transcription elongation factor complex. Is expressed in several structures, including epithelium,ganglia,gut section,head epidermis primordium,and imaginal disc. Used to study congenital heart disease. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder 68,cervical cancer,dystonia 28, childhood-onset,gastrointestinal system cancer (multiple),and hematologic cancer (multiple). Orthologous to human KMT2A (lysine methyltransferase 2A) and KMT2B (lysine methyltransferase 2B). [provided by Alliance of Genome Resources, Jul 2025]
Alternative Names
TXN ADF SASP TRDX TRX1 ATL-derived factor Surface-associated sulphydryl protein
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.