ICC/IF
AF488 staining on IF;Sample: U2OS cellPrimary Ab: 30µg/ml Mouse Anti-Human AXIN2 AntibodySecond Ab: 2μg/ml AF488-Linked Caprine Anti-Mouse IgG Polyclonal Antibody| Product Name | Monoclonal Antibody to Axis Inhibition Protein 2 (AXIN2) |
|---|---|
| Antibody Type | Primary Antibodies |
| Immunogen | RPC192Hu01-Recombinant Axis Inhibition Protein 2 (AXIN2) |
| Clonality | Monoclonal |
|---|---|
| Isotype | IgG1Kappa |
| Host Species | Mouse |
| Tested Applications | ICC/IF |
| ICC/IF: 5-30µg/mL |
|
| Species Reactivity | Human |
| Concentration | 1mg/ml |
| Purification | Protein A/G |
| Gene Symbol | AXIN2 |
|---|---|
| Gene Synonyms | AXIL,ODCRCS |
| Gene Full Name | axin 2 |
| Gene Summary | The Axin-related protein, Axin2, presumably plays an important role in the regulation of the stability of beta-catenin in the Wnt signaling pathway, like its rodent homologs, mouse conductin/rat axil. In mouse, conductin organizes a multiprotein complex of APC (adenomatous polyposis of the colon), beta-catenin, glycogen synthase kinase 3-beta, and conductin, which leads to the degradation of beta-catenin. Apparently, the deregulation of beta-catenin is an important event in the genesis of a number of malignancies. The AXIN2 gene has been mapped to 17q23-q24, a region that shows frequent loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in this gene have been associated with colorectal cancer with defective mismatch repair. [provided by RefSeq, Jul 2008] |
| Alternative Names | Axil Conductin Axin Related Protein Axin-like protein |
ICC/IF
AF488 staining on IF;Sample: U2OS cellPrimary Ab: 30µg/ml Mouse Anti-Human AXIN2 AntibodySecond Ab: 2μg/ml AF488-Linked Caprine Anti-Mouse IgG Polyclonal Antibody| Application Notes | ICC/IF: 5-30µg/mL |
|---|
| Form | Liquid |
|---|---|
| Storage Instructions | Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles. |
| Storage Buffer | 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol. |
