Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades type IV and V collagens. Studies in rhesus monkeys suggest that the enzyme is involved in IL-8-induced mobilization of hematopoietic progenitor cells from bone marrow, and murine studies suggest a role in tumor-associated tissue remodeling. [provided by RefSeq, Jul 2008]
Alternative Names
GELB Gelatinase B CLG4B CLG4-B 92 KDa Gelatinase 92kDa Type IV Collagenase
Figure. Western Blot,Sample: Recombinant MMP9, Human.
Application Notes
ICC/IF: 5-20µg/mL WB:1:200-1:2000
Additional Information
Form
Liquid
Storage Instructions
Store at 4°C for frequent use. Stored at -20°C in a manual defrost freezer for two year without detectable loss of activity. Avoid repeated freeze-thaw cycles.